@ Brown University
PUBLICATIONS
At Brown University
(2014-Present)
22 Brugger C, Sriirangam S, . Deaconescu AM. IraM Remodels the RssB Segmented Helical Linker to Stabilize SigmaS against Degradation by ClpXP
Biorxiv (2023)
21 Brugger C, Schwartz J, Filipovski M,. Deaconescu AM. Structure of Phosphorylated-Like RssB Reveals an Interface Switch for Activation,
Biorxiv (2022)
20. Vadgama N, Kreymerman A, Campbell J, Shamardina O, Brugger C, Genomic England Research Consortium, Deaconescu AM, Lee RT, Penkett C, Gifford CA, Mercola M, Nasir J, Karakikes I. SARS-CoV-2 Susceptibility and ACE2 Gene Variations Within Diverse Ethnic Backgrounds. Frontiers in Genetics (2022)
19. Deaconescu AM. Mfd - At the Crossroads of DNA Repair, Transcriptional Regulation and Molecular Evolvability. Transcription
(2021) 12 (4): 156-170
18. Brugger C and Deaconescu AM. A Gel-based Assay for Protein Translocation on dsDNA. Bio-protocol (2021) 11(14)
17. Schwartz J, Son J, Brugger C, Deaconescu AM. Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB. Protein Science (2021) (4):899-907
16. Brugger C, Zhang C, Suhanovsky M, Kim DD, Sinclair AN, Lyumkis D, Deaconescu AM. Molecular Determinants for dsDNA Translocation by the Transcription-Repair Coupling and Evolvability Factor Mfd. Nature Communications (2020) 11: 1-12
15. Dorich V, Brugger C, Tripathi A, Hoskins J, Tong S, Suhanovsky M, Wicker S, Gottesman S, Deaconescu AM. Structural basis for inhibition of a response regulator of σS stability by a ClpXP antiadaptor. Genes & Development (2019) 33(11-12):718-732
14. Vemu A, Szcecsna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu A.M., Roll-Mecak A. Severing Enzymes Amplify Microtubule through Lattice Through GTP-Tubulin Incorporation. Science (2018) 361:6404
13. Le T.T., Yang Y., Tan C., Suhanovsky M.M., Fulbright R.M., Inman J.T., Li M., Perelman S., Roberts J.W., Deaconescu A.M., Wang M.D. Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism. Cell (2018) 172:344-357
12. Deaconescu, A.M.* and Suhanovsky, M.M. From Mfd to TRCF and Back Again - A Perspective of Bacterial Transcription-Coupled DNA
Repair. Photochemistry and Photobiology (2017) 93 (1): 268-279 (*invited and corresponding author)
11. Kutter, S., Eichner, T., Deaconescu, A.M., Kern, D. Regulation of microtubule assembly by Tau and not Pin1. J. Mol. Biol. (2016) 428(9): 1742-1759
10. Szyk, A.*, Deaconescu, A.M.*, Spector, J.*, Goodman, B., Valenstein, M.L., Ziolkowska, N.E., Kormendi, V., Grigorieff, N., Roll-Mecak, A. Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase. Cell (2014) 157(6): 1405-1415 (*equal contribution) [previewed by Kull & Sloboda, Cell (2014) 157(6): 1255-12256 and recommended by Faculty of 1000]
Authored before Joining Brown University
(2002-2013)
9. Deaconescu, A.M.,# RNA Polymerase between Lesion Bypass and DNA Repair (2013) Cellular and Mol. Life Sciences (2013) 70(23):4495-509 (# invited author)
8. Deaconescu, A.M.,*,# Artsimovitch, I, Grigorieff, N. Interplay of DNA Repair and Transcription- from Structures to Mechanisms (2012) Trends Biochem. Sci. 37(12):543-52 (*corresponding author, # invited author)
7. Deaconescu, A.M., Sevostyanova, A, Artsimovitch, I., Grigorieff, N., NER Machinery Recruitment by Transcription-Repair Coupling Factor Involves Unmasking of a Conserved Intramolecular Interface (2012) Proc. Natl. Acad. Sci. USA 109(9):3353-3358
6. Szyk, A., Deaconescu, A.M., Piszczek, G., Roll-Mecak, A. Tubulin Tyrosine Ligase Structure Reveals Adaptation of an Ancient Fold to Bind and Modify Tubulin. (2011) Nat Struct Mol Biol. 18(11):1250-8 [cover article]
5. Okada, K., Bartolini, F., Deaconescu, A.M., Moseley, J.B., Dogic, Z., Grigorieff, N., Gundersen, G.G., Goode, B.L. The Tumor suppressor protein APC is a potent nucleator of actin assembly that synergizes with the formin mDia1. (2010) J Cell Biol 189:1087-96 [highlighted in Leslie, M. J Cell Biol (2010) 189(7): 1055 and evaluated as a “must read” by Faculty of 1000]
4. Deaconescu, A.M., Savery, N.J., Darst, S.A. The bacterial transcription-repair coupling factor. Curr Opin Struct Biol (2007) 1:96-102
3. Deaconescu, A.M., Chambers, A.L., Smith A.J., Nickels, B.E., Hochschild, A., Savery, N.J., Darst, S.A. Structural Basis for Bacterial Transcription-Coupled DNA Repair. Cell (2006) 124(3): 507-520 [reviewed in Molloy, S. Nature Rev. Microbiology (2006) 4, 240-241 and rated as a “must read” by Faculty of 1000]
2. Deaconescu, A.M. and Darst, S.A. Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor. Acta Cryst. F (2005) F61: 1062-1064
1. Deaconescu, A.M, Roll-Mecak, A., Bonanno, J.B., Kycia, H., Gerchman, S.E., Studier, W., and Burley, S.K. X-ray Structure of Saccharomyces cerevisiae Homologous Mitochondrial Matrix Factor Hmf1. Proteins (2002) 48(2): 431