@ Brown University
PUBLICATIONS
At Brown University
(2014-Present)
20. Vadgama N, Kreymerman A, Campbell J, Shamardina O, Brugger C, Genomic England Research Consortium, Deaconescu AM, Lee RT, Penkett C, Gifford CA, Mercola M, Nasir J, Karakikes I. SARS-CoV-2 Susceptibility and ACE2 Gene Variations Within Diverse Ethnic Backgrounds. Frontiers in Genetics (2022)
19. Deaconescu AM. Mfd - At the Crossroads of DNA Repair, Transcriptional Regulation and Molecular Evolvability. Transcription
(2021) 12 (4): 156-170
18. Brugger C and Deaconescu AM. A Gel-based Assay for Protein Translocation on dsDNA. Bio-protocol (2021) 11(14)
17. Schwartz J, Son J, Brugger C, Deaconescu AM. Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB. Protein Science (2021) (4):899-907
16. Brugger C, Zhang C, Suhanovsky M, Kim DD, Sinclair AN, Lyumkis D, Deaconescu AM. Molecular Determinants for dsDNA Translocation by the Transcription-Repair Coupling and Evolvability Factor Mfd. Nature Communications (2020) 11: 1-12
15. Dorich V, Brugger C, Tripathi A, Hoskins J, Tong S, Suhanovsky M, Wicker S, Gottesman S, Deaconescu AM. Structural basis for inhibition of a response regulator of σS stability by a ClpXP antiadaptor. Genes & Development (2019) 33(11-12):718-732
14. Vemu A, Szcecsna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu A.M., Roll-Mecak A. Severing Enzymes Amplify Microtubule through Lattice Through GTP-Tubulin Incorporation. Science (2018) 361:6404
13. Le T.T., Yang Y., Tan C., Suhanovsky M.M., Fulbright R.M., Inman J.T., Li M., Perelman S., Roberts J.W., Deaconescu A.M., Wang M.D. Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism. Cell (2018) 172:344-357
12. Deaconescu, A.M.* and Suhanovsky, M.M. From Mfd to TRCF and Back Again - A Perspective of Bacterial Transcription-Coupled DNA
Repair. Photochemistry and Photobiology (2017) 93 (1): 268-279 (*invited and corresponding author)
11. Kutter, S., Eichner, T., Deaconescu, A.M., Kern, D. Regulation of microtubule assembly by Tau and not Pin1. J. Mol. Biol. (2016) 428(9): 1742-1759
10. Szyk, A.*, Deaconescu, A.M.*, Spector, J.*, Goodman, B., Valenstein, M.L., Ziolkowska, N.E., Kormendi, V., Grigorieff, N., Roll-Mecak, A. Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase. Cell (2014) 157(6): 1405-1415 (*equal contribution) [previewed by Kull & Sloboda, Cell (2014) 157(6): 1255-12256 and recommended by Faculty of 1000]
Authored before Joining Brown University
(2002-2013)
9. Deaconescu, A.M.,# RNA Polymerase between Lesion Bypass and DNA Repair (2013) Cellular and Mol. Life Sciences (2013) 70(23):4495-509 (# invited author)
8. Deaconescu, A.M.,*,# Artsimovitch, I, Grigorieff, N. Interplay of DNA Repair and Transcription- from Structures to Mechanisms (2012) Trends Biochem. Sci. 37(12):543-52 (*corresponding author, # invited author)
7. Deaconescu, A.M., Sevostyanova, A, Artsimovitch, I., Grigorieff, N., NER Machinery Recruitment by Transcription-Repair Coupling Factor Involves Unmasking of a Conserved Intramolecular Interface (2012) Proc. Natl. Acad. Sci. USA 109(9):3353-3358
6. Szyk, A., Deaconescu, A.M., Piszczek, G., Roll-Mecak, A. Tubulin Tyrosine Ligase Structure Reveals Adaptation of an Ancient Fold to Bind and Modify Tubulin. (2011) Nat Struct Mol Biol. 18(11):1250-8 [cover article]
5. Okada, K., Bartolini, F., Deaconescu, A.M., Moseley, J.B., Dogic, Z., Grigorieff, N., Gundersen, G.G., Goode, B.L. The Tumor suppressor protein APC is a potent nucleator of actin assembly that synergizes with the formin mDia1. (2010) J Cell Biol 189:1087-96 [highlighted in Leslie, M. J Cell Biol (2010) 189(7): 1055 and evaluated as a “must read” by Faculty of 1000]
4. Deaconescu, A.M., Savery, N.J., Darst, S.A. The bacterial transcription-repair coupling factor. Curr Opin Struct Biol (2007) 1:96-102
3. Deaconescu, A.M., Chambers, A.L., Smith A.J., Nickels, B.E., Hochschild, A., Savery, N.J., Darst, S.A. Structural Basis for Bacterial Transcription-Coupled DNA Repair. Cell (2006) 124(3): 507-520 [reviewed in Molloy, S. Nature Rev. Microbiology (2006) 4, 240-241 and rated as a “must read” by Faculty of 1000]
2. Deaconescu, A.M. and Darst, S.A. Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor. Acta Cryst. F (2005) F61: 1062-1064
1. Deaconescu, A.M, Roll-Mecak, A., Bonanno, J.B., Kycia, H., Gerchman, S.E., Studier, W., and Burley, S.K. X-ray Structure of Saccharomyces cerevisiae Homologous Mitochondrial Matrix Factor Hmf1. Proteins (2002) 48(2): 431