Deaconescu Laboratory

PUBLICATIONS

19. Deaconescu AM.  Mfd - At the Crossroads of DNA Repair, Transcriptional Regulation and Molecular Evolvability (in press)

 

18. Brugger C and  Deaconescu AM. A Gel-based Assay for Protein Translocation on dsDNA. Bio-protocol (2021) 11(14)

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17. Schwartz J, Son J, Brugger C, Deaconescu AM. Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB. Protein Science (2021) (4):899-907 

 

16. Brugger C, Zhang C, Suhanovsky M, Kim DD, Sinclair AN, Lyumkis D, Deaconescu AM. Molecular Determinants for dsDNA Translocation by the Transcription-Repair Coupling and Evolvability Factor Mfd. Nature Communications (2020) 11: 1-12

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15. Dorich V, Brugger C, Tripathi A, Hoskins J, Tong S, Suhanovsky M, Wicker S, Gottesman S, Deaconescu AM. Structural basis for inhibition of a response regulator of σS stability by a ClpXP antiadaptor. Genes & Development (2019) 33(11-12):718-732

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14. Vemu A, Szcecsna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu A.M., Roll-Mecak A.   Severing Enzymes Amplify Microtubule through Lattice Through GTP-Tubulin Incorporation. Science (2018) 361:6404 

 

13. Le T.T., Yang Y., Tan C., Suhanovsky M.M., Fulbright R.M., Inman J.T., Li M., Perelman S., Roberts J.W., Deaconescu A.M., Wang M.D.  Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism. Cell (2018) 172:344-357 

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12. Deaconescu, A.M.* and Suhanovsky, M.M. From Mfd to TRCF and Back Again - A Perspective of Bacterial Transcription-Coupled DNA

Repair.  Photochemistry and Photobiology (2017) 93 (1): 268-279  (*invited and corresponding author)

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11. Kutter, S., Eichner, T., Deaconescu, A.M., Kern, D.  Regulation of microtubule assembly by Tau and not Pin1.  J. Mol. Biol. (2016) 428(9): 1742-1759 

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10. Szyk, A.*, Deaconescu, A.M.*, Spector, J.*, Goodman, B., Valenstein, M.L., Ziolkowska, N.E., Kormendi, V., Grigorieff, N., Roll-Mecak, A.  Molecular Basis for Age-Dependent Microtubule Acetylation by Tubulin Acetyltransferase.  Cell (2014)  157(6): 1405-1415  (*equal contribution) [previewed by Kull & Sloboda, Cell (2014) 157(6): 1255-12256 and recommended by Faculty of 1000]

9. Deaconescu, A.M.,# RNA Polymerase  between Lesion Bypass and DNA Repair (2013) Cellular and Mol. Life Sciences  (2013) 70(23):4495-509 (# invited author)

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8. Deaconescu, A.M.,*,# Artsimovitch, I,  Grigorieff, N. Interplay of DNA Repair and Transcription- from Structures to Mechanisms (2012) Trends Biochem. Sci. 37(12):543-52 (*corresponding author, # invited author)

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7. Deaconescu, A.M.,  Sevostyanova, A, Artsimovitch, I., Grigorieff, N., NER Machinery Recruitment by Transcription-Repair Coupling Factor Involves Unmasking of a Conserved Intramolecular Interface (2012) Proc. Natl. Acad. Sci. USA 109(9):3353-3358

 

6. Szyk, A., Deaconescu, A.M., Piszczek, G., Roll-Mecak, A.  Tubulin Tyrosine Ligase Structure Reveals Adaptation of an Ancient Fold to Bind and Modify Tubulin. (2011) Nat Struct Mol Biol. 18(11):1250-8 [cover article]

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5. Okada, K., Bartolini, F., Deaconescu, A.M., Moseley, J.B., Dogic, Z., Grigorieff, N., Gundersen, G.G.,  Goode, B.L.  The Tumor suppressor protein APC is a potent nucleator of actin assembly that synergizes with the formin mDia1. (2010) J Cell Biol 189:1087-96 [highlighted in Leslie, M. J Cell Biol (2010)  189(7): 1055 and evaluated as a “must read” by Faculty of 1000]

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4. Deaconescu, A.M., Savery, N.J., Darst, S.A.  The bacterial transcription-repair coupling factor. Curr Opin Struct Biol (2007) 1:96-102

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3. Deaconescu, A.M., Chambers, A.L., Smith A.J., Nickels, B.E., Hochschild, A., Savery, N.J., Darst, S.A.  Structural Basis for Bacterial Transcription-Coupled DNA Repair.  Cell (2006) 124(3): 507-520 [reviewed in Molloy, S. Nature Rev. Microbiology (2006) 4, 240-241 and rated as a “must read” by  Faculty of 1000]

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2. Deaconescu, A.M. and Darst, S.A.  Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor.  Acta Cryst. F (2005) F61: 1062-1064

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1. Deaconescu, A.M, Roll-Mecak, A., Bonanno, J.B., Kycia, H., Gerchman, S.E., Studier, W.,  and Burley, S.K.  X-ray Structure of Saccharomyces cerevisiae Homologous Mitochondrial Matrix Factor Hmf1. Proteins (2002) 48(2): 431